Confirmation of DNA sequences of novel HPV types and assignment of type numbers

The International Human Papillomavirus Reference Center receives clones of potentially novel HPV types, clones them again and re-sequences them. If the confirmed sequence is found to represent a novel type, a unique HPV type number is assigned.

HPV classification is based on the nucleotide sequence of the gene coding for the capsid protein L1 (de Villiers et al.,2004Bernard et al.,2010):

  • HPV types belonging to different genera share less than 60% similarity.
  • Different HPV species within a genus share between 60 and 70% similarity.
  • A novel HPV type has less than 90% similarity to any other HPV type.

Species and genus names are assigned by Papillomaviridae Study Group of International Committee on Taxonomy of Viruses .

Submit a putative novel HPV type

The cloned putative novel HPV type should be sent to the Interational HPV Reference Center together with the sequence. The HPV genome can be cloned in more than 1 plasmid.

OBS: Genomes of some of the HPV types are not available at public databases. To avoid wasting time and resources on cloning of “new” HPVs that are actually already known, we strongly recommend to send original HPV sequences to International Human Papillomavirus Reference Center where we will check and confirm their novelty.

Request a clone for academic research

The International Human Papillomavirus Reference Center distributes samples of the reference clones, for academic research use, under Material Transfer Agreements agreed upon with the originator.

To request a clone: contact the reference center with information on which HPV types you are interested in. If we have permission from the owner to distribute the HPV type a MTA will be sent out to the requesting laboratory for signing.

Order a proficiency panel

To register for the HPV DNA proficiency panel and get more information contact EQUALIS: